With 8 points to make up on the leading two and tricky away matches to come on Saturday, could Man Utd and Arsenal find themselves out of the title race before December?
Pick of the matches is at Twickenham with a repeat of last year's World Cup Final between England and South Africa, where England will be looking to reverse their 15-6 defeat in Paris.
Coral make South Africa the narrow favourites at 4/5, with England at Evens and 16/1 the draw.
"England vs South Africa is one of the highlights of a busy weekend of sport, and along with Wales vs New Zealand and also Scotland and Ireland at home, it looks like a feast for Rugby Union fans," said Coral spokesman Gary Burton.
"England vs South Africa is always one of the great matches, and with England on home soil, and what looks like a close game on paper, they will be looking to reserve their unlucky defeat in Paris last October and are only marginal underdogs at Evens, with the Springboks the slight favourites at 4/5."
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